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In primary cortical neuronal cultures from ARE-hPAP mice (E15), tBHQ (tert-butylhydroquinone), a prototypical Nrf2-ARE activator, increased hPAP activity 30 to 50 fold and indicated that the hPAP activity was induced primarily in the astrocyte 21 , 13

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Hyperoxia induces retinal vascular endothelial cell apoptosis through formation of peroxynitrite